Antimicrobial and toxicity studies on Breynia disticha and Vernonia elaeagnifolia

Saad Touqeer

Abstract


The present study was aimed to investigate the phytochemistry, toxicity and antimicrobial activity of the two plants Breynia disticha and Vernonia elaegnifolia. Tests for all the major secondary metabolites were carried out whereas acute toxicity studies on rabbits and cytotoxic studies on Artemia salina were performed. Antibacterial and antifungal activities were tested using disk diffusion method. The phytochemical investigation revealed the presence of flavonoids, tannins and other important compounds in the two plants. Antibacterial and antifungal activity was found to be present in both plants. Both plants exhibited no toxicity in in-vitro and in-vivo assays. The present work thus proves the medicinal use of the two safe and potent plants.


Keywords


Plants; Extracts; Activity; Phytochemistry; Alkaloids; Flavonoids; Glycosides.

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References


Brevoort P (1998). The blooming U.S. botanical market: a new overview. Herbalgram., USA, pp. 33-46.

Farnsworth NR (1988). Biodiversity. Wilson EO. National academy Press., Washington DC, pp. 83-97.

Laloo S, Pampersad F.S, Bunde A, Mahaerg L, Swkha JD, Teelucksiry L, McDouyau AA and Adesiyun AA (2000). Bacteriological quality of raw oyster in Trinidad and the attitude knowledge and perception of the public about its consumption. Int. Journal of Food Microbiology., 54: 99-107

De Boer HJ (2012). Snake Gourds, Parasites and Mother Roasting: Medicinal plants, plant repellents, and Trichosanthes (Cucurbitaceae). PhD thesis., Uppsala Univ.

Lorence DH, Flynn TW, Wagner WL, Evenhuis NL and Miller SE (1995). Contributions to the flora of Hawai'i. III. New additions, range extensions, and rediscoveries of flowering plants. Bishop Museum Occasional Papers., 41: 19-58

Matthew KM (1995). An excursion flora of central Tamilnadu, India. CRC Press., India, pp. 269

Sulayman Abid, Saad Touqeer. (2015). Antimicrobial and antioxidant activity of Breynia disticha and Vernonia elaeagnifolia. J. App. Pharm., 7: 178-182

Harborne JB (1973). Phytochemical Methods. Chapman and Hall., London, pp. 49-188.

Raaman N (2006). Phytochemical techniques. New India Publishing., New Delhi, pp. 15-44.

Trease GE and Evans WC (1983). Pharmacognosy. 12th Ed. Saunders., New York. Pp. 27-36.

Khan A, Rahman M and Islam S (2008). Antipyretic activity of Peperomia pellucida leaves in rabbit. Turk. J. Biol., 32: 37-41

Wadood A, Wadood N and Shah SA (1989). Effects of Acacia arabica and Caralluma edulis on blood glucose levels of normal and alloxan diabetic rabbits. J. Pak. Med. Assoc., 39: 208-212.

Hussain F, Hameed I, Dastagir G, Khan I and Ahmad B (2010). Cytotoxicity and phytotoxicity of some selected medicinal plants of the family Polygonaceae. Afr. J. Biotechnol., 9: 770-774

Bauer AW, Kirby WM, Sherris JC and Turck M (1966). Antibiotic susceptibility testing by a standardized single disk method. Am. J. Clin. Path., 45: 493-496

Saratha V and Subramanian SP (2010). Evaluation of antifungal activity of Calotropis Gigantea latex extract: An in vitro study. Int. J. Pharm. Sci. Res., 1: 88-96

Khan J, Saeed MA, Touqeer S, Adnan S, Masood Z, Zaman M (2014). Antihyperglycemic, Hypoglycemic and Cytotoxic Activity of Albizia lebbek and Trigonella corniculata. RJPT., 7: 191-195




DOI: https://doi.org/10.22200/pjpr.20172%25p

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