Effect of ethanolic extract of Pericampylus glaucus (Lam) Merr on Biochemical parameters in high fats diets Sprague-Dawley rats

Muhammad Kifayat Ullah, Mohd Shahimi Mustapha, Md. Moklesur Rahman Sarker


DOI: http://dx.doi.org/10.22200/pjpr.201711-8

Abstract


The use of natural remedies for the treatment of hyperlipidemia and obesity has a long history. The herbal products today symbolize safety in contrast to the synthetic drugs that are regarded as unsafe to human. The genus Pericampylus glaucus (Lam) Merr belongs to the family of menispermaceae, which is commonly found in Malaysia. Several species of this family are known to exhibit a wide range of pharmacological activities. The objective of the present study was to evaluate the effect of P. glaucus (Lam) Merr extract on biochemical parameters in high fats diets Sprague Dawley rats (SD rats). The anti-hyperlipidemic potential of P. glaucus (Lam) Merr was studied in Sprague Dawley rats. The high-fat diets along with standard rat normal laboratory rodent diet were given for 28 days along with the treatment of tested plant extract and standard drugs. The animals used for the study were treated with simvastatin at dose 80 mg/kg body weight and ethanol extract of P. glaucus at a dose of 400, 600, and 800 mg/kg (body weight) daily for the whole 28 days of experiment. The weight of treated rats was measured weekly and the analysis of serum lipids was carried out at the end of the study.

Result showed that the ethanolic extract of P. glaucus produced a significant reduction in body weight (P < 0.05, P < 0.01, P < 0.001, total cholesterol (moms/l), triglyceride (mmol/l), low density lipoprotein (mmol/l), uric acid (mmol/l) levels, and significant increased (P < 0.05, P < 0.01, P < 0.001) in high density lipoproteins (mmol/l) in different dosed of crude extract treated group and standard drug in high fat diet rats when compared to hyperlipidemic group.

The present work indicates that the crude extract of P. glaucus significantly suppressed high lipids profiles in high fat diet treated rats, justifying and suggesting the antihyperlipidemic potential of P. glaucus.


Keywords


Ethanolic extract; Pericampylus glaucus; HFD; Sprague-Dawley rats (SD rats).

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DOI: http://dx.doi.org/10.22200/pjpr.201711-8

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